*Single-blind, randomized, parallel-group study of 127 patients with moderate-to-severe periodontitis who had at least 5 teeth with ≥5 mm pocket depths. Mean RCB numbers at day 30 were reduced from 18.9 x 105 to 9.50 x 105 (50%) by ARESTIN + SRP (p=0.002) and from 19.3 x 105 to 14.2 x 105 (26%) by SRP alone (p=0.002).

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†In 2 multicenter, investigator-blind, parallel-design studies of 748 patients with generalized moderate to advanced adult periodontitis characterized by a mean probing depth of 5.90 and 5.81 mm, subjects received 1 of 3 treatments: (1) SRP, (2) SRP + vehicle, and (3) SRP + ARESTIN. Retreatment occurred at 3 and 6 months after initial treatment, and any new site with pocket depth ≥5 mm also received treatment. Patients treated with ARESTIN were found to have statistically significantly reduced probing pocket depth compared with those treated with SRP alone or SRP + vehicle at 9 months after initial treatment. ARESTIN vs SRP alone (n=250) p<0.01; ARESTIN vs vehicle + SRP (n=249) p<0.001; ARESTIN + SRP vs vehicle (n=249) p<0.001.

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‡Subpopulation (n=101) of combined, single-blind, Phase III trial comparing ARESTIN + SRP to SRP alone and SRP + placebo (n=748). SRP was performed for all groups at baseline. ARESTIN or vehicle was administered to periodontal pockets ≥5 mm in the adjunctive therapy groups at baseline, 3 months, and 6 months. Efficacy was evaluated over 9 months. At 9 months, ARESTIN + SRP had a 58% greater therapeutic effect vs. SRP alone in periodontal patients with cardiovascular disease (P≤0.001). 

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§Subpopulation (n=271) of combined, single-blind, Phase III trials comparing ARESTIN + SRP to SRP alone and SRP + placebo (n=748). SRP was performed for all groups at baseline. ARESTIN or vehicle was administered to periodontal pockets ≥5 mm in the adjunctive therapy groups at baseline, 3 months, and 6 months. Efficacy was evaluated over 9 months. At 9 months, ARESTIN + SRP had a 29% greater therapeutic effect vs. SRP alone in smokers (P≤0.001). 

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||Subpopulation (n=109) of combined, single-blind, Phase III trial comparing ARESTIN + SRP to SRP alone and SRP + placebo (n=748). SRP was performed for all groups at baseline. ARESTIN or vehicle was administered to periodontal pockets ≥5 mm in the adjunctive therapy groups at baseline, 3 months, and 6 months. Efficacy was evaluated over 9 months. At 9 months, ARESTIN + SRP had a 33% greater therapeutic effect vs. SRP alone in patients over the age of 50 (P≤0.001). 

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REFERENCES: 1. Williams RC, Paquette DW, Offenbacher S, et al. Treatment of periodontitis by local administration of minocycline microspheres: a controlled trial. J Periodontol. 2001;72(11):1535-1544. 2. ARESTIN® (minocycline hydrochloride) Microspheres, 1 mg. Prescribing Information. OraPharma; Bridgewater, NJ. 3. Bland PS, Goodson JM, Gunsolley JC, et al. Association of antimicrobial and clinical efficacy: periodontitis therapy with minocycline microspheres. J Int Acad Periodontol. 2010;12(1):11-19. 4. Socransky SS, Haffajee AD. Dental biofilms: difficult therapeutic targets. Periodontol 2000. 2002;28:12-55.